Study of TLBZT Based Herbal Therapy Plus Chemotherapy for Metastatic Colorectal Cancer

Inclusion Criteria: * Histologically confirmed adenocarcinoma of the colon or rectum with non-resectable metastatic disease; * Ages between 18 and 70 years; * Measurable lesion; * Karnofsky Performance Status ≥ 60%; * Estimated life expectancy of at least 6 months; * Participants have no major organ dysfunction and chemotherapy contraindications: hemoglobin ≥90g/L, N \> 1.5×10\^9/L, platelet≥ 100×10\^9/L, normal liver and kidney function; * Informed consent from the patient. Exclusion Criteria: * Symptomatic brain metastasis; * Adjuvant or neo-adjuvant treatment for non-metastatic disease in past 6 months; * Serious disease of heart, liver, kidney with severe dysfunction; * Serious complications, such as gastrointestinal tract obstruction and hemorrhage; * Pregnancy or breast-feeding women; * Mental or cognitive disorders; * Be participating other drug trials; * Who are allergic to the study drug.