A Phase 1B Dose-escalation and Phase 2a Study of Carotuximab (TRC105) in Combination With Pazopanib in Patients With Advanced Soft Tissue Sarcoma

Inclusion Criteria: 1. Histologically confirmed unresectable soft tissue sarcoma that has progressed following treatment with chemotherapy. Prior pazopanib is allowed if the drug was not discontinued for toxicity ( Phase 1b only) 2. Histologically confirmed metastatic soft tissue sarcoma that has progressed by RECIST following treatment with anthracycline chemotherapy. Patients may have received up to four lines of systemic therapy for metastatic disease and no more than two lines of combination treatment ( Phase 2 only) 3. Histologically confirmed locally advanced (e.g. unresectable) or metastatic angiosarcoma that has progressed following treatment with prior systemic therapy. Progression must be documented on or following the most recent systemic therapy. Prior pazopanib is allowed if the drug was not discontinued for toxicity (Phase 2 angiosarcoma cohorts only) 4. Measurable disease by RECIST 5. Age of 12 years or older (patient must weigh ≥ 40 kg) 6. ECOG performance status ≤ 1 7. Resolution of all acute adverse events resulting from prior cancer therapies to NCI CTCAE grade ≤ 1 or baseline (except alopecia or neuropathy) 8. Adequate organ function. 9. Willingness and ability to consent for self to participate in study 10. Willingness and ability to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures 11. Available archival tumor specimen of the soft tissue sarcoma that meets inclusion criterion #1, #2 or #3 Exclusion Criteria: 1. Prior treatment with TRC105 2. Prior treatment with a VEGFR TKI (including pazopanib) (Phase 2 only) 3. Current treatment on another therapeutic clinical trial 4. Receipt of systemic anticancer therapy, including investigational agents, within 28 days of starting study treatment. 5. No major surgical procedure or significant traumatic injury within 6 weeks prior to study registration, and must have fully recovered from any such procedure; date of surgery (if applicable) or the anticipated need for a major surgical procedure within the next six months. 6. Patients who have received wide field radiotherapy ≤ 28 days or limited field radiation for palliation \< 14 days prior to cycle 1 day 1 or those patients who have not recovered adequately from side effects of such therapy 7. Uncontrolled chronic hypertension 8. Significant ascites or pericardial or pleural effusion 9. History of brain involvement with cancer, spinal cord compression, or carcinomatous meningitis, or new evidence of brain or leptomeningeal disease. 10. Angina, MI, symptomatic congestive heart failure, cerebrovascular accident, transient ischemic attack, arterial embolism, pulmonary embolism, PTCA or CABG within the past 6 months. Deep venous thrombosis within 6 months, unless the patient is anti-coagulated without the use of warfarin for at least 2 weeks. In this situation, low molecular weight heparin is preferred. 11. Active bleeding or pathologic condition that carries a high risk of bleeding. Patients who have been uneventfully anti-coagulated with low molecular weight heparin are eligible. 12. Thrombolytic use (except to maintain i.v. catheters) within 10 days prior to first day of study therapy 13. Known active viral or nonviral hepatitis or cirrhosis 14. History of hemorrhage or hemoptysis within 3 months of starting study treatment 15. History of peptic ulcer within the past 3 months of treatment 16. History of gastrointestinal perforation or fistula in the past 6 months, or while previously on antiangiogenic therapy, unless underlying risk has been resolved 17. Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illness 18. Receipt of a strong CYP3A4 inducer within 12 days prior to cycle 1 day 1 or a strong CYP3A4 inhibitor within 7 days prior to cycle 1 day 1. 19. Pregnancy or breastfeeding. Female patients must be surgically sterile (i.e.: hysterectomy) or be postmenopausal, or must agree to use effective contraception during the study and for 3 months following last dose of TRC105. All female patients of reproductive potential must have a negative pregnancy test (serum or urine) within 7 days prior to first dose. Male patients must be surgically sterile or must agree to use effective contraception during the study and for 3 months following last dose of TRC105. The definition of effective contraception will be based on the judgment of the Principal Investigator or a designated associate. 20. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgment of the Investigator, would make the patient inappropriate for this study.