Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21

Phase 2UnknownNCT01975545

Universidad Autonoma de San Luis Potosí20 enrolled

Overview

Patients with trisomy 21 are in greater danger of developing caries. It has been hypothesized that adding silver nanoparticles to fluor varnishes could promote remineralization of the teeth. A split-plot randomized controlled trial will be performed to address this question.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Down Syndrome

Interventions

Fluor varnishDRUG

Dental varnish will be applied to one anterior superior teeth in a random side.

Fluor varnish with nanoparticlesDRUG

Dental varnish with silver nanoparticles will be applied to one anterior superior teeth in a random side.

Eligibility

Sex: ALLMin age: 1 YearMax age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with trisomy 21 diagnosed through caryotype * Age 1 to 6 years old * Any sex * White spot present in both upper anterior teeth * Parental agreement to participate in the study Exclusion Criteria: * Hypersensibility to any of the substances used * Non cooperating patients * Caries in enamel or dentine in the upper anterior teeth * Leukemia or diabetes * Dental fluorosis present

Locations (1)

Universidad Autónoma de San Luis Potosí

San Luis Potosí City, San Luis Potosí, Mexico

Outcomes

Primary Outcomes

Remineralization

Remineralization status will be assessed through laser fluorescence of the tooth with a Diagnodent probe (Diagnodent, Kavo, Madrid, Spain)

Time frame: 3 months

Data from ClinicalTrials.gov

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