Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD)

N/AUnknownNCT01976130

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau45 enrolled

Overview

Study hypothesis: Chronic Obstructive Pulmonary Disease (COPD) patients with chronic bacterial colonization have lower levels of mucins and antimicrobial peptides in their airways

Main objective: (1) To investigate the expression of mucins and antimicrobial peptides in patients with severe COPD and their relationship with the presence of bacteria in the airway

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Bacterial Infection in COPD

Interventions

BronchoscopyPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * COPD Exclusion Criteria: * Acute exacerbation in the last 4 weeks

Locations (1)

Hospital de la Santa Creu i Sant Pau

Barcelona, Barcelona, Spain

Outcomes

Primary Outcomes

Mucins in sputum

Time frame: Day 1

Secondary Outcomes

Antimicrobial peptides in sputum

Time frame: Day 1

Data from ClinicalTrials.gov

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