A Study in Cancer Patients to Evaluate the Effect of a Single Dose of NKTR-102 (Etirinotecan Pegol) on the QTc Interval and to Assess Pharmacokinetics and Safety

Inclusion Criteria: * Advanced or metastatic solid tumor refractory to standard therapy * Measurable or non-measurable disease * Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 * Resolution of acute toxic effects of prior chemotherapy and other cancer treatments * Left ventricular ejection fraction (LVEF) ≥50% by echocardiogram * Adequate bone morrow and organ function * Electrolytes within normal limits * Stopped tobacco use for 4 weeks prior to day 1 and during the study * Agree to use adequate contraception Exclusion Criteria: * Previous anti-cancer therapy for malignancy within 4 weeks (6 weeks for the nitrosoureas or mitomycin C) before day 1 * Treatment with antiarrythmic drugs and any medication known to cause QTc prolongation within 4 weeks before screening and during the study * Prior extensive anthracycline exposure * Administration of cytochrome P450 CYP3A4 inducers and inhibitors within 4 weeks before day 1 and during the study * Intake of grapefruit, grapefruit juice, Seville oranges, or other products containing grapefruit or Seville oranges within 14 days prior to day 1 and during the study * History of serious cardiovascular disease * Abnormal systolic blood pressure, diastolic blood pressure and/or heart rate * History of additional risk factors for Torsade de Pointes * Prolonged QTcF * Important abnormalities of the ECG that may interfere with the interpretation of QTc interval changes at screening * Implantable pacemaker or automatic implantable cardioverter defibrillator * UGT1A1 genotype of TA 7 in both alleles (homozygous UGT1A1\*28) or TA 8 in either one or both alleles (hetero- or homozygous for UGT1A1\*37) * Any major surgery within 4 weeks prior to day 1 * Concurrent treatment with other anticancer therapy * Untreated central nervous system metastases * Chronic or acute GI disorders resulting in diarrhea * Pregnancy or lactation