Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis

N/ACompletedNCT01976884

Changhai Hospital71 enrolled

Overview

Immunosuppression is the leading cause of death in septic patients. Neutrophils are classical components of innate immunology, but recent studies showed that neutrophils might display antigen presenting function and inhibit lymphocyte proliferation by expressing programmed cell death 1 ligand 1 (PD-L1). Whether neutrophils express PD-L1 and its role in immunosuppression during sepsis remain unclear.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sepsis Immunosuppression

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with severe sepsis * patients with sepsis after PCNL for infectious kidney stone * patients with pancreatic cancer * healthy volunteers Exclusion Criteria: * patients with immunodeficient diseases * patients who accept glucocorticoid or immunosuppressant * patients with an age older than 18 years * patients providing the informed consent

Outcomes

Primary Outcomes

PD-L1 level on neutrophils

PD-L1 level on neutrophils was compared between different populations.

Time frame: within 24h after recruitment

Secondary Outcomes

28-day mortality

Time frame: 28 days after diagnosis of sepsis

Data from ClinicalTrials.gov

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