General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer

N/ACompletedNCT01978717

Changhong Miao53 enrolled

Overview

The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Colorectal Neoplasms

Interventions

epidural anesthesiaPROCEDURE

general anesthesiaPROCEDURE

Patients received general anesthesia for surgery

Eligibility

Sex: ALLMin age: 51 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with Colorectal Cancer(CRC); * subjected to the Fast-Track processing of surgery; * between 18 and 75 years old. Exclusion Criteria: * American Society of Anesthesiologists(ASA) grade \> III; * BMI \> 30; * a history of abdominal surgery, endocrine or immune system dysfunction; * recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month; * previous contraindication to epidural anesthesia.

Locations (1)

Zhong Shan Hospital Fudan University

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

The changes of peripheral immune cells and cytokines

The changes of peripheral subtype of T-helper, myeloid-derived suppressor cells(MDSCs) and cytokines

Time frame: within the first 5 days after surgery

Data from ClinicalTrials.gov

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