A Study of MHAA4549A in Healthy Volunteers in an Influenza Challenge Model

Inclusion Criteria: * In good health with no history of major medical conditions from medical history, physical examination and routine laboratory tests * Male subjects and women of child-bearing potential must use effective contraception as defined by protocol, starting at entry to quarantine and continuing until Day 120 follow-up visit * Sero-suitable for challenge virus Exclusion Criteria: * Women who have been pregnant within 6 months prior to the study, or who have been breastfeeding within 3 months prior to the study, or who have a positive pregnancy test at any point in the study * Any history or evidence of any clinically significant cardiovascular, gastrointestinal, endocrinological, haematological, hepatic, immunological, metabolic, urological, neurological, psychiatric, renal, and/or other major disease or malignancy, as judged by the CI * Abnormal pulmonary function evidenced by clinically significant abnormalities in spirometry * History of asthma, COPD, pulmonary hypertension, reactive airway disease, or chronic lung disease of any etiology. A history of childhood asthma before the age of 12 is acceptable provided the subject is asymptomatic without treatment. * History suggestive of respiratory infection within 14 days prior to admission to the unit