A Study of the Elimination, Pharmacokinetics, and Metabolism of RO5424802

Inclusion Criteria: * Male adults, 18 to 45 years of age, inclusive * Body mass index (BMI) from 18 to 32 kg/m2, inclusive * Willingness to use effective contraception as outlined in the protocol * Willingness to abstain from alcohol and xanthine-containing beverages or food (coffee, tea, cola, chocolate and "energy drinks") from 72 hours prior to the first dose until discharged * Willingness to avoid prolonged sun exposure and guard against sunburn during study \& follow-up Exclusion Criteria: * Clinically significant medical history or findings in physical examination, vital signs, or laboratory test results prior to study start * Positive screening tests for hepatitis B or C, HIV, alcohol, drugs of abuse, or tobacco * Regular smoking within 6 months prior to first dosing. Subjects should avoid smoky environments for at least 1 week prior to each cotinine screen * Excessive alcohol consumption * Use of any metabolic inducers (including herbals such as St. John's Wort) within 4 weeks or 5 half-lives (whichever is longer) before the first dose of study medication, including but not limited to: rifampin, rifabutin, glucocorticoids, carbamazepine, phenytoin and phenobarbital * Regular work with ionizing radiation or radioactive material * Subjects enrolled in a previous radiolabel study or who have received radiotherapy within 12 months prior to first dosing such that total radioactivity over a 12 month period would exceed an acceptable radiation burden \> 0.1 mSv * Exposure to radiation for diagnostic reasons (except dental X-rays and plain X-rays of thorax and bony skeleton \[excluding spinal column\]), during work or participation in a medical trial in the previous year * Strenuous activity, sunbathing, or contact sports are not allowed from 4 days prior to entry into the clinical site until study follow-up * Participation in an investigational drug or device study within 60 days (or 6 months for biologic therapies) prior to first dosing