Voice Analysis Using the LPC (Linear Predictive Coding)Method for the Prediction of Aspiration

N/AWithdrawnNCT01981239

Ulsan University Hospital

Overview

It was well known that aspiration is the primary cause of an aspiration pneumonia among the dysphagia patients. In order to predict the degree of an aspitation,video-fluoroscopic-swallowing study and fiberoptic-endoscopic swallowing evaluation have been developed, but those evaluations are invasive and allowed only in a limited condition. In this study, as a precedent study for the non-linear analysis, voice analysis using LPC method will be evaluated. The superiority of LPC method will be compared with a spectral analysis using Jitter and Simmer as a positive control. This clinical study will be performed prospective, positive-controlled, single-blind (i.e. assessor-blind),and single cohort clinical trial for efficacy

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Conditions

Deglutition Disorder

Interventions

VFSSDEVICE

VFSS was perfomred one day before or after the voice sampling in the same patients according to the guideline of modified Longeman's protocol.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who were referred for VFSS Exclusion Criteria: * Patients cannot phonate d/t tracheostomy * Preexisting oro-laryngo-pharyngeal disease * Patients cannot follow 1 step command * Patients cannot maintain a phonation for 3 seconds * Refusal of participation * Patients who were not classified for the candidate by physicians * Patients who coughs following drinking of 5ml normal saline

Locations (1)

Ulsan University Hospital

Ulsan, South Korea

Outcomes

Primary Outcomes

LPC index

Voice sampling before and immediately after drinking of 20ml N/S and linear analysis using LPC method

Time frame: one day before or after VFFS

Secondary Outcomes

Spectral Analysis

Voice sampling is performed before and immediately after drinking of 20ml N/S and HNR (dB), RAP (%: Jitter), Mean and SD Fundamental Frequency (Hz: Fo), Shimmer (%) and SNR (dB) are calculated using Dr. Speech program.

Time frame: one day before or after VFFS

LPC anaysis

Voice sampling is performed before and immediately after drinking of 20ml N/S and residual variance, coefficiency mean, coeffiency variance, and coeffiency skewness are computed using LPC analysis program.

Time frame: one day after or before VFSS

Risk group

According to Penetration-aspiration scale, patients are classified into high-risk patients (grade IV-VIII) and low-risk patients (grade I-III) by using the data derived from videofluoroscopic swallowing study

Time frame: whithin one hour of VFSS

Data from ClinicalTrials.gov

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