Reactogenicity, Safety and Immunogenicity of a Live Monovalent A/17/CALIFORNIA/66/395 (H2N2) Influenza Vaccine

Inclusion Criteria: * Legal male or female adult aged 18 through 40 years * Literate and willing to provide written informed consent. * A signed informed consent. * Free of obvious health problems, as established by medical history and screening evaluations, including physical examination. * Capable and willing to complete diary cards and willing to return for all follow-up visits * Willing to comply with the rules of isolation unit (including willing and able to take oseltamivir influenza antiviral medication, should that be recommended by study physician). * For females, willing to take reliable birth control measures through day 56. Exclusion Criteria: * Participation in another clinical trial involving any therapy within the previous three months or planned enrollment in such a trial during trial period. * Receipt of any non-study vaccine within four weeks prior to enrollment or refusal to postpone receipt of such vaccines until four weeks after study completion. * Practice of nasal irrigation on a regular basis within the past six months or has engaged in nasal irrigation within two weeks prior to enrollment. * Recent history of frequent nose bleeds (\>5 within the past year). * Clinically relevant abnormal paranasal anatomy. * Recent history (within the past month) of rhino or sinus surgery, or surgery for any traumatic injury of the nose. * Current or recent (within two weeks of enrollment) acute respiratory illness with or without fever. * Other acute illness at the time of study enrollment. * Receipt of immune globulin or other blood products within three months prior to study enrollment or planned receipt during period of subject participation in the study. * Chronic administration (defined as more than 14 consecutively-prescribed days) of immunosuppressants and/or other immune-modulating therapy within six months prior to study enrollment. * Participation in any previous trial of any H2N2 containing influenza vaccine. * History of asthma. * Hypersensitivity after previous administration of any influenza vaccine. * History of wheezing after past receipt of any live influenza vaccine. * Other adverse event (AE) following immunization (body temperature more than 40°C, collapse, non-febrile seizures, anaphylaxis), at least possibly related to previous receipt of any vaccine (not only influenza). * Suspected or known hypersensitivity to any study vaccine components, including chicken or egg protein. * Seasonal (autumnal) hypersensitivity to the natural environment * Acute or chronic clinically significant pulmonary, cardiovascular, hepatic, metabolic, neurologic, psychiatric or renal functional abnormality, as determined by medical history, physical examination or clinical laboratory screening tests, which in the opinion of the investigator, might interfere with the study objectives. Subjects with physical examination findings or clinical laboratory screening results which would be graded 2 or higher on the AE severity grading scale (see Attachments) will be excluded from entry into the study and will be excluded from receipt of dose two of study vaccine or placebo. * History of leukemia or any other blood or solid organ cancer. * History of thrombocytopenic purpura or known bleeding disorder. * History of seizures. * Known or suspected immunosuppressive or immunodeficient condition of any kind, including HIV infection. * Known chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. * Known tuberculosis infection or evidence of previous tuberculosis exposure. * History of chronic alcohol abuse and/or illegal drug use. * Claustrophobia or sociophobia. * Pregnancy or lactation. * Any condition that, in the opinion of the investigator, would increase the health risk to the subject if participates in the study or would interfere with the evaluation of the study objectives. * Allergic, including anaphylactic, reactions to the introduction of any vaccines (not only influenza) in the subject's medical history