Spicy Diet on Salty Taste and Salt Intake

N/ACompletedNCT01982669

Zhiming Zhu606 enrolled

Overview

Excess dietary salt intake is closely associated with the development of hypertension and cardiocerebral vascular diseases. Reduction in high salt intake significantly prevents hypertension and cardiocerebral events. Currently, few promising method is available to reduce salt intake in human. This study focus on examining the salty taste in population-level and exploring whether dietary factors can reduce salt intake through acting on salty taste.

Hypertension and its related complications are common health problems that can lead to multiple organ damage and death. Excessive salt intake plays very important role in the development of hypertension. Reducing salt intake prevents high blood pressure as well as cardiocerebral vascular diseases. The experimental design is a multi-center, random-order, double-blind observational study to investigate the salty taste and salt intake in population-level. A total of 606 individuals from four cities in China are recruited in this study. This study aims to explore the salty taste characterization and salt intake in participants who like or dislike spicy diet through questionnaire, spicy preference, salty perception and super-threshold as well as the 24-hour urinary sodium excretion.

Study Type

OBSERVATIONAL

Enrollment

606

Conditions

Salty Taste Spicy Diet

Interventions

No InterventionOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years and ≤ 55 years. * Willing and able to provide written informed consent. * Willing and able to comply with all study procedures. Exclusion Criteria: * Hypogeusia or loss due to neural system disease or oral and digestive disease. * Capsaicin allergy and poor compliance. * Recently oral diuretics and participate in other pharmacological experiment in 3 months. * Acute infection, cancer, serious arrhythmias, drug or alcohol abuse. * Currently have cold, fever, acidosis, dehydration, diarrhea, vomiting during the study. * Unwilling or unable to communication due to the dysnoesia and language disorders * Severe neural or psychiatric diseases that would preclude fully understand and corporation in the study. * Pregnancy or lactation * Unwilling to sign the informed consent

Locations (1)

Daping Hospital, The Third Military Medical University

Chongqing, Chongqing Municipality, China

Outcomes

Primary Outcomes

Effects of spicy diet on salt taste

Daily spicy food intake was evaluated by diet questionnaire and salty taste was tested through salt perception and super-threshold examination on the first day when the participant was investigated.

Time frame: Day 1

Secondary Outcomes

Effects of spicy diet on salt intake

Daily spicy food intake was evaluated by diet questionnaire on the first day when the participant was investigated and then 24-hour urine was collected during the following day and salt intake was assessed by 24-hour urinary sodium excretion.

Time frame: Day 1

Effects of spicy diet on obesity parameters.

Daily spicy food intake was evaluated by diet questionnaire and body mass index and waist circumference were measured on the first day when the participant was investigated.

Time frame: Day 1

Effects of spicy diet on blood pressure

Daily spicy food intake was evaluated by diet questionnaire and systolic and diastolic blood pressure were measured on the first day when the participant was investigated.

Time frame: Day 1

Data from ClinicalTrials.gov

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