tDCS Combined With Constraint Induced Movement Therapy and Role of GABA Activity in Stroke Recovery

Inclusion Criteria: * stroke onset \>3 months prior to study enrollment * subject has at least 10 degrees mobility over wrist, thumb and fingers on the affected side * subject can move, stand up and stand firmly with constrained healthy hand * subject can perform training 6 hours daily in 2 weeks * subject is able to understand instructions and be able to cooperate Exclusion Criteria: * pregnancy * contraindications to MRI of brain * epilepsy, major psychiatric disease * excessive pain that prevents training * history of other diseases resulting decreased mobility of affected upper limb