Heavy sedation or sleep is a common problem within the intensive care unit (ICU) using our standard intravenous medications. This commonly leads to confusion, low blood pressure, slow wake up and removal of the artificial breathing tube (extubation), which prolongs ICU stay. Using inhaled volatile anesthetic agents are likely to improve these patient outcomes. This unique project is the first North American study looking at using volatiles for patients who need longer-term ICU sedation. This project has excellent potential at lowering these complications and improving quality of care, which will lower patient ICU stay and healthcare costs.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Ottawa Heart Institute
Ottawa, Ontario, Canada
Toronto General Hospital, University Health Network
Toronto, Ontario, Canada
atmospheric volatile concentration
Daily assessment of atmospheric volatile levels will be measured using photometric multigas infrared analyzer
Time frame: daily
Sedation
adherence to the volatile sedation, sedation will be guided by explicit protocols targeting a Sedation-Agitation Score (SAS) of 3-4
Time frame: daily
Feasibility
assess rate of patient recruitment and barriers to recruitment
Time frame: 2 years
Education Tool
multidisciplinary feedback regarding teaching package, protocol, quality of sedation
Time frame: 2 years
serum fluoride levels
Measurements will be taken 24 hours post sedation and every 2 days until while on sedation followed by 2 further samples after discontinuation of sedation.
Time frame: every 2 days
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