Single Dose Escalation Trial to Evaluate the Safety, Tolerability Pharmacokinetics and Pharmacodynamics of GSK3050002

Inclusion Criteria: * Male aged between 18 and 65 years of age inclusive, at the time of signing the informed consent. * Healthy as determined by a responsible and experienced physician, based on a medical evaluation including medical history, physical examination, laboratory tests and 12- lead ECG. A subject with a clinical abnormality or laboratory parameter(s) which is/are not specifically listed in the inclusion or exclusion criteria may be included only if the Investigator in consultation with the GSK Medical Monitor \[if required\] agree and document that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures. * Body mass index (BMI) within the range 18 - 29 kilogram per meter square \[kg/m\^2\] (inclusive). * Male subjects with female partners of child-bearing potential must agree to use one of the listed contraception methods. This criterion must be followed for 1 month prior to the first dose of study medication for 15 weeks post dose. * Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form. * Suitable for cannulation and with adequate venous access. * Alanine aminotransferase (ALT), alkaline phosphatase and bilirubin \<= 1.5xUpper limit of Normal \[ULN\] (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35%). * Based on a single ECG QTcF \< 450 milliseconds (msec). Exclusion Criteria: * Criteria Based Upon Medical Histories * Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones). * History of regular alcohol consumption within 6 months of the study defined as: an average weekly intake of \>21 units. One unit is equivalent to 8 grams (g) of alcohol: a half-pint (approximately 240 milliliter \[mL\]) of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits. * History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation. * History of severe drug allergies including type 1 hypersensitivity reaction to parental administration of contrast agents, human or murine proteins or monoclonal antibodies. * Subject has acne which requires prescription treatment * Criteria Based Upon Diagnostic Assessments * A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening * A positive pre-study drug/alcohol screen. * A positive test for Human immunodeficiency virus (HIV) antibody. * Subject is a heavy smoker as defined by a positive smoking breath test of \>10 parts per million (ppm) carbon monoxide (CO). * Other Criteria * Evidence of current or at risk of developing bacterial, fungal, or viral infection at screening or within 7 days before dosing. * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer). * Subject is unable to refrain from taking prescription or non-prescription drugs (including vitamins and dietary or herbal supplements), within 7 days prior to the first dose of study medication until completion of the follow-up visit, unless in the opinion of the Investigator and sponsor the medication will not interfere with the study. * Subject is unable to abstain from travelling to area which carry a high risk of infection for the duration of the study. * Exposure to more than four new chemical entities within 12 months prior to the first dosing day. * Subject is unable to abstain from being vaccinated or immunized for 4 weeks prior to dosing and for 19 weeks after the study.