Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors. Results from genetic studies reveal one pathway associated with susceptibility to ASDs, which includes synaptic cell adhesion molecules. Among the factors that could modulate this pathway are the genes controlling circadian rhythms. Sleep disorders and low melatonin levels are frequently observed in ASDs. Thus investigator will characterize the circadian rhythms of patients with ASD and search for circadian rhythms genes polymorphisms.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
42
* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer * 25 childs with urinary sample, Circadian rhythms assessed with actometer
* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer * 25 childs with urinary sample, Circadian rhythms assessed with actometer
Henri Mondor Hospital
Créteil, France
Urinary sulfatoxymelatonin secretion
Time frame: The determination will be performed at 14 days ( child)
Urinary sulfatoxymelatonin secretion
Time frame: The determination will be performed at 21 days ( adults)
Core body temperature rhythm
Time frame: The determination will be performed at 5 days (adult)
Circadian rhythms assessed with actometer
Time frame: The determination will be performed at 14 ( child) and 21 days (adult)
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