Cow Milk Allergy (CMA) occurs in 2 to 5 % of all infants. Reflux, regurgitation and vomiting are well recognised symptoms of CMA. The recommended treatment of CMA is an extensive hydrolysate. The North American Society of Pediatric Gastroenterology Hepatology and Nutrition (NASPGHAN) \& the European Society of Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) reflux guidelines have no strict recommendations for the treatment of distressed infants with reflux, suspected of CMA. One of the preferred proposed options is to thicken an extensive hydrolysate . This study aims at evaluating the additional value of a thickened extensive hydrolysate in children suspected of CMA and presenting with frequent regurgitation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
72
Universitair Ziekenhuis Brussel
Brussels, Belgium
Hippocration Hospital
Thessaloniki, Greece
Faculty of Medicine, Kuwait university
Safat, Kuwait
Pediatricians
Beirut, Lebanon
University Children's Hospital
Ljubljana, Slovenia
Number of patient dropped out for intolerance
Time frame: 1 month
Vandenplas' regurgitations score
Time frame: 1 month
Cow's milk protein hypersensitivity score
Time frame: 1 month
Growth (weight, height, head circumference)
Time frame: 1 month
Growth (weight, height, head circumference)
Time frame: 3 months
Growth (weight, height, head circumference)
Time frame: 6 months
Number of daily regurgitations
Time frame: 1 month
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