The Efficacy of Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome

Inclusion Criteria: * 1\) must have experienced bladder pain, urinary urgency and urinary frequency, for at least 6 months prior to entry into the study 2) Pain VAS ≥4 3) O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) symptom and problem ≥ 12( and pain ≥2, and nocturia ≥ 2) 4) PUF score ≥ 13 5) cystoscopic record within 2 years Exclusion Criteria: 1. Patients who are pregnancy or, childbearing age without no contraception 2. Patients with voided volume \<40 or, \> 400ml 3. Patients with microscopic hematuria, (≥1+ in dipstick), If not excluded that no evidence of neoplastic tumor examination 4. Patients with urine culture showing evidence of urinary tract infection 1month prior to the study 5. Accompanied medical problem below * Tuberculosis in urinary system * Bladder cancer, urethral cancer, prostate cancer * Recurrent cystitis * anatomical disorder 6. Patients had prior surgery (eq, bladder augmentation, cystectomy 7. Patients with neurologic disorder 8. Patients with indwelling catheter or intermittent self-catheterization 9. Patients with psychologic problem