Injection of Hormone to Enhance Implantation in Embryo Transfer After IVF

N/ACompletedNCT01986374

Servy Massey Fertility Insititute75 enrolled

Overview

The endometrium is deprived of signals form the embryo in IVF conditions. Studies suggest that placing HCG into the uterus prior to embryo transfer can enhance implantation.

The study is in pilot phase, uncontrolled. The risks appear to be minimal and there are conflicting new reports being announced. A small amount of fluid with HCG is injected into the uterus. HCG is a potent signal to the uterus for preparation for implantation. This is not a funded study. Three published studies suggest the approach is valid; one refutes the concept.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Infertility

Interventions

HCG is introducedDRUG

must have good blastocysts

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 47 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- infertility patients undergoing IVF with good expectation of two embryos day 3 or day 5. must speak and read English. Includes donor eggs. Exclusion Criteria:abnormal uterus \-

Locations (1)

Servy Massey Fertility Insititute

Atlanta, Georgia, United States

Outcomes

Primary Outcomes

HCG enhances pregnancy rate

compare pregnancy rates to established clinical norms.

Time frame: 9 months.

Secondary Outcomes

implantation rate

compare implantation rate per embryo to clinical norms.

Time frame: 18 months

ongoing pregnancy rate

compare success to clinical norms

Time frame: 22 months

Data from ClinicalTrials.gov

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