Nerve blocks are used to decrease the amount of pain you have after surgery. We are asking you to take part in a research study. This research study will test whether adding a medicine called clonidine to nerve blocks helps to improve them. Nerve blocks typically last less than a day after surgery. We are looking for ways to make them work better and last longer. Clonidine is approved for use as a blood pressure medicine. Its use in nerve blocks is investigational, but it may help nerve blocks to last longer. Adding clonidine to nerve blocks may also decrease the amount of pain medicine a person has after surgery. All people who enter this study will receive a nerve block with the normal medicine, but half of people will also have clonidine added to their nerve block. This study will enroll 60 participants from UAB hospitals.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
14
University of Alabama at Birmingham
Birmingham, Alabama, United States
Mean Time to Onset of Sensory and Motor Block Between the Study Group and the Control Group
Mean time onset of sensory block and motor block between the study group and the control group to assess the efficacy of clonidine to prolong the block duration.
Time frame: baseline to 72 hours
Compare the Mean Duration of Sensory and/or Motor Block Between the Study Group and the Control Group
Mean duration of sensory and/or motor block between the study group and the control group to assess the efficacy of clonidine to prolong the block duration.
Time frame: baseline to 72 hours
Compare the Mean VAS Scores at 24 Hours Post Procecure to Determine the Effectiveness of Perineural Clonidine on Duration of Postoperative Analgesia Between the Control Group and Study Group
The VAS score is measured as 0 - 10 with 0 being no pain to 10 being the worst pain imaginable to assess the efficacy of clonidine to control postoperative pain and patient satisfaction at the time of discharge.
Time frame: baseline to 24 hours post block
Compare the Opioid Consumption During the First 24 Hours Between the Study Group and the Control Group
Mg equivalent of morphine consumption during the first 24 hours between the study group and the control group
Time frame: baseline to 24 hours post block
Compare the Subjects Mean Arterial Blood Pressure Effect of Perineural Clonidine Versus Placebo
Comparing the mean arterial blood pressure between the study group and the control group to assess the effect of clonidine on blood pressure.
Time frame: baseline to discharge from hospital (expected 3 days)
the Mean Time to Discharge After Start of Procedure for Each Group - Control and Study Group.
Comparing the mean hours from start of procedure to discharge between the study group and the control group
Time frame: baseline to discharge (approximately 72 hours)
Mean Time to First Analgesic Intake Postoperative Between the Control Group and the Study Group.
Comparing the mean time to the first analgesic intake postoperative between the control group and the study group
Time frame: baseline to 24 hours post block
Compare the Mean VAS Scores at 24 Hours Post Procedure to Determine the Patient Satisfaction on Duration of Postoperative Analgesia Between Control Group and Study Group
Compare the mean VAS scores at 24 hours between the study group and the control group to assess the efficacy of clonidine to control postoperative pain and patient satisfaction at the time of discharge.
Time frame: baseline to 24 hours
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