Cetuximab IRDye800 Study as an Optical Imaging Agent to Detect Cancer During Surgical Procedures

Inclusion Criteria: 1. Biopsy confirmed diagnosis of squamous cell carcinoma of the head and neck. 2. Patients diagnosed with any T stage, any subsite within the head and neck that are scheduled to undergo surgical resection. Patients with recurrent disease or a new primary will be allowed. 3. Planned standard of care surgery with curative intent for squamous cell carcinoma 4. Age ≥ 19 years 5. Have life expectancy of more than 12 weeks 6. Karnofsky performance status of at least 70% or ECOG/Zubrod level 1 7. Have acceptable hematologic status, coagulation status, kidney function, and liver function including the following clinical results: * Hemoglobin ≥ 9gm/dL * Platelet count ≥ 100,000/mm3 * Magnesium, potassium and calcium greater than or equal than the lower limit of normal range per institution normal lab values * TSH \<10 micro International Units/mL Exclusion Criteria: 1. Received an investigational drug within 30 days prior to first dose of cetuximab-IRDye800 2. Had within 6 months prior to enrollment: MI, CVA, uncontrolled CHF, significant liver disease, unstable angina 3. Inadequately controlled hypertension with or without current antihypertensive medications 4. History of infusion reactions to cetuximab or other monoclonal antibody therapies. 5. Women who are pregnant or breast feeding 6. Patients who have a grade 2 or greater reaction with the test/loading cetuximab dose. 7. Evidence of QT prolongation on pretreatment ECG (greater than 440 ms in males or greater than 450 ms in females). 8. Lab values that in the opinion of the primary surgeon would prevent surgical resection. 9. Patients receiving Class IA (quinidine, procanamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents. 10. Patients with TSH\>11