Multi-Center Study To Examine The Use Of Flex HD® And Strattice In The Repair Of Large Abdominal Wall Hernias

Inclusion Criteria: * 18 years of age or greater * Have a BMI \<40 * Have a hernia of at least 200 cm\^2 * Have no contraindications to test material(s) * Have a life expectancy greater than 1 year in the opinion of the Investigator * Able to provide informed consent * Able and willing to return for scheduled study visits over 1 year post-operatively (following research related surgery) Exclusion Criteria: * \< 18 years of age * Subject is determined to have an America Society of Anesthesiologists' (ASA) physical class of 4, 5, or 6. * Have a BMI \> 40 * Have a hernia \< 2002 cm * Have abdominal loss of domain such that the operation would be impractical or would adversely affect respiratory or cardiovascular function to an unacceptable degree in the opinion of the Investigator * Inability to close the fascia primarily without abdominal wall mobilization or component separation * Participation in an investigational drug or device study within the past 6 weeks prior to enrollment into this trial * Have active necrotizing fasciitis or any other known active local or systemic infection * Have a known collagen metabolism disorder or any medical condition that could interfere with normal tissue healing process as determined by the Investigator * Have a known active malignancy present and/or had chemotherapy 12 weeks prior to screening or planned chemotherapy within 12 weeks of enrollment with the exception of BCC or SCC * Have known moderate to severe cirrhosis which in the opinion of the Investigator would impact the outcome of this trial * Have a life expectancy less than 1 year. * Be unable to participate in the informed consent process * Be unable or unwilling to return for scheduled study visits over the 1 year post-operative assessment period * Subject's ventral hernia is related to an organ transplant surgery * Received high dose steroids (≥100mg of prednisone) within the past 6 weeks * Tobacco use within the past 6 weeks or positive serum cotinine test at time of admission * Uncontrolled diabetes (i.e. known HbA1C value \> 7%) * History of drug addiction (recreational drugs, prescription drugs or alcohol) that in the Investigator's opinion may interfere with protocol assessments and/or the subject's ability to complete the required follow up * Pregnancy and/or breastfeeding * Enterocutaneous fistula * Undergoing concomitant panniculectomy * Ventral hernia repairs involving actively infected mesh removal * Inability to obtain primary fascial closure (Intra-operatively)