MRI Study of Radiation-Induced Damage to White Matter and Blood-Brain-Barrier

Inclusion Criteria: * Patients receiving partial brain irradiation for malignant or benign brain tumors (including low-grade gliomas, high-grade gliomas, malignant meningioma, pituitary adenomas, supratentorial meningioma, or craniopharyngiomas); or patients receiving whole brain irradiation for brain metastases. * Patients must be 18 years of age or older * Patients must sign a study specific consent form approved by the Institutional Review Board (IRB) of the University of Michigan prior to study entry. * Patients must have a neurological function class 1 or 2 with a Karnofsky performance status (a scoring system used to quantify general well being and quality of life on a scale of 100 to 0) of greater than or equal to 70. * Patients must have an expected life expectancy of greater than 6 months. Exclusion Criteria: * Patients with a history of major medical illness or psychiatric impairment which, in the investigator's opinion, will prevent administration of the protocol. * Patients who have had prior external beam irradiation to the brain or head/neck area that will lead to overlap of the radiation field. * Patients should have no contraindications to having a contrast enhanced Magnetic Resonance Imaging (MRI) scan. * Prisoners are excluded. * Pregnant women are excluded.