Gene Polymorphism Study of Normal Individual Inflammasome Genes

N/AWithdrawnNCT01988805

Ohio State University

Overview

This study is intended to collect blood from healthy individuals to investigate whether variations in immune-related (inflammasome) genes affect how the immune cells found in the blood can help fight infections and prevent diseases.

Study Type

OBSERVATIONAL

Conditions

Healthy Individuals

Interventions

Blood DrawOTHER

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Healthy with no chronic or acute illnesses, or taking medication which in the opinion of the PI would impact the analyses being conducted. 2. At least 18 years or older. 3. Are capable of reading, understanding and providing written informed consent. Exclusion Criteria: 1. Non-English speaking. 2. Individuals under 18 years old. 3. Woman who believe they are or may be pregnant. (Based on self reporting. Pregnancy testing will not be conducted for the purposes of this study) 4. Individuals experiencing acute or chronic illnesses which in the opinion of the PI would impact the analyses being conducted. 5. Currently taking prescription or over the counter medication which in the opinion of the PI would impact the analyses being conducted. 6. Individual has donated blood more than twice in the last week or the amount to be drawn will exceed the maximum allowance in the last 8 weeks.

Locations (1)

Davis Heart & Lung Research Institute

Columbus, Ohio, United States

Outcomes

Primary Outcomes

analyze their ability to respond to exogenous challenges by changing the production of proteins, the expression of genes and their ability to migrate and ingest materials

Our intent is to collect these cells, divide them into subtypes such as monocytes, lymphocytes and neutrophils and then to analyze their ability to respond to exogenous challenges by changing the production of proteins, the expression of genes and their ability to migrate and ingest materials. We additionally will be interested in examining the cell components that may be released from these cells during various in vitro challenges.

Time frame: one visit

Data from ClinicalTrials.gov

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