The purpose of this study is to evaluate an investigational way to provide radiation therapy to treat breast cancer at the time of surgery. Traditionally, the recommended treatment for early stage breast cancer is surgery to remove the tumor, followed by whole breast radiation therapy to decrease the chance of recurrence of the cancer. Whole breast radiation involves daily radiation treatments for 4-6 weeks and can be associated with damage to other tissues including the skin. Recent technological advances have made it possible to provide radiation treatment during the breast cancer surgical procedure. This procedure is called intraoperative radiation therapy (IORT). The University of Virginia has a unique IORT system which allows for the inclusion of cutting edge imaging technology into the IORT procedure in order to provide delivery of radiation directly to the needed areas and to avoid radiation to other tissues.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
28
IORT is a form of APBI (accelerated partial breast irradiation) that allows for a high degree of dose homogeneity, exclusion of non-affected structures, and reduction of the volume of breast tissue exposed.
University of Virginia Health System
Charlottesville, Virginia, United States
IORT (Intra-operative Radiation Therapy) treatment interval
Evaluation of the time from the acquisition of the initial CT-on-rails until the time at which IORT is complete
Time frame: 90 minutes or less
Overall incidence of adverse events and major toxicities
Time frame: Up to 6 months following treatment
IORT treatment parameters
Gather preliminary data on planning time
Time frame: up to 6 hours
Cosmetic Outcome
Digital photographs will be taken and used to assess breast characteristics (i.e. color/pigmentation, size, shape) and evaluated for cosmetic outcomes
Time frame: Up to 6 months following treatment
Quality of life assessment
Patients will complete a breast cancer specific quality of life survey
Time frame: Up to 6 months following treatment
IORT treatment parameters
gather preliminary data on total radiation delivery time
Time frame: upto 6 hours
IORT treatment parameters
Gather preliminary data on total procedure time
Time frame: upto 6 hours
IORT treatment parameters
Gather preliminary data on dosimetry
Time frame: upto 6 hours
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