IR, Inflammatory and Cardiovascular Markers in PCOS Among Obese and Non-obese Women

N/AUnknownNCT01989039

Taipei Medical University WanFang Hospital800 enrolled

Overview

FPCOS is associated with an adverse cardiometabolic profile, consisting of increased total or central adiposity, increased insulin resistance and abnormal glucose metabolism. Low-grade chronic inflammation predicts cardiovascular outcomes and is observed in women with PCOS. However, obesity is also associated with increased inflammatory markers. Obesity is per se associated with increased adipose expression and plasma levels of leptin, lower expression of adiponectin, and elevated inflammatory markers. To study the insulin resistance、inflammatory markers and cardiovascular risk in women with PCOS, body weight status should be considered. Investigator therefore conduct this retrospective study to evaluate the insulin resistance、inflammatory and cardiovascular markers between PCOS and non-PCOS among obese and non-obese women.

Study Type

OBSERVATIONAL

Enrollment

800

Conditions

Polycystic Ovary Syndrome,Insulin Resistance,

Eligibility

Sex: FEMALEMin age: 13 YearsMax age: 48 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women had been fulfilled with whole anthropometric measurements, clinic and biochemical survey about insulin resistance, cardiovascular and inflammatory markers. Exclusion Criteria: * women who had been diagnosed with malignant tumor, Asherman's syndrome, Mullerian agenesis, ovarian failure, hyperprolactinemia, and chromosomal anomalies; * women who had had menarche less than 1 years before evaluation or who were older than 49; * women who received hormones or drugs for major medical diseases within three months.

IR, Inflammatory and Cardiovascular Markers in PCOS Among Obese and Non-obese Women

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts