The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery. The primary aim is to evaluate the expression of ADBR2 in VAS\>4 patients and to compare it to those with VAS\<4.
Study Type
OBSERVATIONAL
Enrollment
130
Istituto Ortopedico G. Pini
Milan, Milano, Italy
Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients.
Time frame: 4 months after surgery
Expression frequency of OPRM1, COMT, IL1Ra
Time frame: 6, 12, 24, 48 hours
Serum concentration of TNFα, TGFβ, IFNγ, IL-6 and IL-10 obtained with ELISA system
Time frame: 6, 12, 24 and 48 hours postoperatively
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