* hypothesis: sleep restriction in healthy subject trigger alteration of decision making associated with immuno-inflammatory changes * inclusion criterias: healthy subjects, men, under 35 years, BMI\<26, no sleep troubles, intermediate chronotype * design: 12 subjects, longitudinal study 2 days of baseline, 7 night of sleep restriction (4h sleep/night), recovery (1, 2, 3 and 9 normal sleep nights). * parameters: decision making tests, reaction time, wakefulness test, biological parameters (cathecholamines, pro-inflammatory cytokines...), heart rate, blood pressure * control of sleep restriction: continuous polysomnographic survey
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
12
4 hours sleep by night during one week
Institut de recherche biomédicale des armées
Brétigny-sur-Orge, France
London tower test score (décision making)
% of good score and mean response time resulting from London Tower test, assessed during baseline, sleep restriction (day 1 to day 5) and recovery (day 1 to day 3) at 10 AM
Time frame: up to 3 days
wakefulness
Time frame: maintenance of wakefulness test (MWT) score observed every day during baselline, sleep restriction and recovery at 09 AM, 12 AM, 4 PM and 7 PM
cognitive function
Time frame: up to 3 days
Inflammation
Time frame: biological marker of inflammation levels assessed every day during baseline, sleep restriction and recovery at 08 AM
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.