Correlate BRCA1 Protein Expression With Response to DNA Damaging Chemotherapy

Inclusion Criteria: * Metastatic breast cancer and have formalin-fixed, paraffin embedded primary tumor available for testing BRCA1 protein expression * Adults over 18 years of age * Have resolution of all acute toxic effects of any prior chemotherapy or radiotherapy to NCI CTC grade ≤ 1 prior to study registration. * Be informed of the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study specific screening procedures * Be willing and able to comply with the treatment plan, scheduled clinic visits, laboratory and oncological tests and other study procedures * Have a ECOG performance status of 0 - 2 * Measurable disease by CT by RECIST 1.1 to evaluate response * Adequate bone marrow function defined as platelets 100 X 109 cells/L, neutrophils 1.5 x 109 cells/L, white blood cells (WBC) 3.0 x 109 cells/L and a hemoglobin 90 gm/L * Creatinine \< 1.5 mg/dl or creatinine clearance \> 40 ml/min * Liver function tests (AST and or ALT) should be 2 x upper limit of normal (ULN, defined as per laboratory where blood testing is done), total bilirubin 1.5 x ULN (except for patients with liver metastases, ALT and/or ALT 5 times the upper limit of normal is accepted) Exclusion Criteria: * Myocardial infarction within 6 months of registration * Brain metastases unless documented to be controlled post completion of local therapy (surgery and/or radiation therapy) for at least four weeks prior to registration * Pregnant or breast feeding women. Women with child bearing potential must use effective measures to prevent pregnancy while receiving pegylated liposomal doxorubicin * Have a concurrent active non-breast malignancy except for non-melanoma skin cancer * Her2 positive tumors as defined by FDA guidelines(3+ immunohistochemical staining, defined as uniform, intense membrane staining of more than 10% of invasive tumor cells, and for cases with 2+ staining showing gene amplification by FISH, expressed as a ratio of more than 2 when comparing HER-2 gene and chromosome 17 fluorescent signals)