Efficacy and Safety of ARTRA (Glucosamine Plus Chondroitin Sulfate Combination) in Treatment of Chronic Low Back Pain

Inclusion Criteria: 1. Patients aged 40-65 years, inclusively. 2. Pain intensity according to Visual Analogue Scale (VAS) \> 3 points. 3. Duration of back pain \> 12 weeks. 4. Pain reinforcement during movement in lumbar spine. 5. Osteoarthritis, spondylarthrosis, osteochondrosis. 6. Given written Informed consent form for participation in the study. 7. Treatment with ARTRA Exclusion Criteria: 1. History of allergic reactions to chondroprotectors. 2. Participation in another clinical study within 30 days before screening or during this study. 3. Fibromyalgia. 4. Active neoplastic disease, history of neoplastic disease within 3 years before screening. 5. Paget's disease. 6. Degenerative spondylolisthesis. 7. Administration of anticonvulsant, antidepressant, barbiturate, anxiolytic, or muscle relaxant drugs for more than one week prior screening. 8. History of alcohol or drug abuse. 9. Frequent episodes of nausea, dyspepsia, pain in the epigastric region, diarrhea, face and extremities edema, dizziness and headache. 10. History of any disease that, in the opinion of the investigator, might confound the results of the study or poses an additional risk to the subject during participation in the study 11. Clinically significant renal disorders. \-