Processing the Digital Imaging and COmmunications in Medicine (DICOM) of tomographic using Mannheim Lung Analyzing software (MALUNA®) , to obtain volumetrical and densitometric data of brain tissue after patients with severe brain trauma
Quantitative analysis of brain and structures in it, in terms of volume, weight and density, in patients with severe brain trauma, using MALUNA dedicated software to process DICOM images. 1. st endpoint: compare these data with those obtained by CT scans analysis of patients that recur to this kind of diagnostic investigation for non-traumatic events and with negative diagnostic related to cerebral pathological implication. 2. nd endpoint: relate data obtained with clinical evaluation of the patient (cerebral physiology and outcome) 3. rd endpoint: evaluate differences in terms of volume, weight and density of brain and its structures, between patients with diffuse cerebral injury and those with localized lesions.
Study Type
OBSERVATIONAL
Enrollment
60
Azienda ospedaliera ospedale Circolo e Fondazione Macchi
Varese, Italy
The evaluation of volumetrical and densitometric data of brain tissue of patients with severe brain trauma
Time frame: Participants will be followed for 8 days
The evaluation of consciousness.
During the observation are evaluated: • Glasgow Coma Scale (GCS).
Time frame: Participants will be followed for 8 days
The evaluation of clinical conditions.
During the observation are evaluated multiparametric arterial and venous gas analysis : partial pressure of oxygen in arterial blood(PaO2); partial pressure of carbon dioxide in the arterial blood (PaCO2); cerebral venous oxygen saturation (SjO2); arterial oxygen saturation (SaO2); measure of the acidity or basicity of an aqueous solution (pH); base excess (B.E.); bicarbonate ion (HCO3-); sodium ion (Na+); potassium ion (K+); glycemia; blood concentration of hemoglobin(Hb); hematocrit (Ht).
Time frame: Participants will be followed for 8 days
The evaluation of brain pressures
During the observation are evaluating: • Intracranial Cerebral Pressure (ICP) if monitored and perfusional cerebral pressure(PCP);
Time frame: Participants will be followed for 8 days
The evaluation of cardiac monitoring.
During the observation are evaluating: • Mean arterial pressure (MAP), cardiac frequency (FC), body temperature, water balance, diuresis;
Time frame: Participants will be followed for 8 days
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