Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation

N/ACompletedNCT01991119

Samsung Medical Center98 enrolled

Overview

the purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion

Atrial fibrillation is the most common arrhythmia requiring continuous therapy. Conversion to and maintenance of sinus rhythm is important. Propafenone and dronedarone has been used as treatment for maintenance of sinus rhythm after DC cardioversion. But there are no direct comparison study. The purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Atrial Fibrillation

Interventions

PropafenoneDRUG

DronedaroneDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * a patient with persistent atrial fibrillation who received successful DC cardioversion Exclusion Criteria: * prior amiodarone use * NYHA class III or IV heart failure * Left ventricular ejection fraction \< 35% * second or third AV block * sick sinus syndrome * heart rate \< 50 beat per minute * myocardiac infarction within 3 months * pregnant women * severe hepatic dysfunction * QT prolongation \> 500ms or PR interval \> 180ms * history of hypersensitivity for drug

Locations (1)

Cardiac and Vascular Center

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

recurrence of atrial fibrillation

Time frame: 6 month

Data from ClinicalTrials.gov

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