Suitability of DCE-MRI for Detection of Vascular Changes After VBT

N/ACompletedNCT01991808

Abramson Cancer Center at Penn Medicine16 enrolled

Overview

This is a pilot study of DCE MR imaging to detect vascular changes in the vagina during and after radiotherapy n patients receiving adjuvant brachytherapyfor cervical or endometrial cancer.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Carcinoma of the Cervix, Carcinoma or Carcinosarcoma of the Uterus

Interventions

RadiotherapyRADIATION

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Must be 18 years of age. * Must have histologically confirmed carcinoma of the cervix, carcinoma or carcinosarcoma of the uterus. * Subjects are receiving intracavitary brachytherapy. * ECOG performance status of 0-2. * Creatinine clearance 30. Exclusion Criteria: * Subjects with an inability to tolerate MR imaging (i.e. claustrphobia) * Study subjects who have contraindication to MRI scanning such as but not limited to subjects with pacemakers, metal fragments in the eye or certain metallic implants. * Patients who do not speak or read English.

Locations (1)

Abramson Cancer Center of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

Number of Participants With Adverse Events

Time frame: 2 years

Data from ClinicalTrials.gov

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