This research study provides a novel opportunity to examine the intra-prostatic tumour inhibitory effects of statins in men with prostate cancer undergoing surgery.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
33
HMG-CoA reductase inhibitors that lowers cholesterol levels. 40mg twice daily
University Health Network- The Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Pre and post treatment effect on the Ki-67 proliferation index
Time frame: Week 8
Comparison of immunohistochemical staining in Biopsy and post-RP tissues
Will measure: i. Apoptosis (caspase 3) ii. Signaling (Rap1A, Rap, RhoB) iii. Mevalonate pathway proteins (HMG-CoA reductase, HMG-CoA synthase, SREBP1/2, mevalonate decarboxylase, GGPS1, GGT, FT) iv. Tumour Infiltrating Lymphocytes (TILs), CD3 (T-cells), CD20 (B-cells), CD68 (macrophages), CD56 (NK cells), IDO (negative control)) v. Growth and survival signaling (AKT, P-AKT, ERK, P-ERK)
Time frame: Week 8
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