Cryoablation of Small Breast Tumors in Early Stage Breast Cancer

Inclusion Criteria: 1. Age ≥ 50 2. Unifocal primary invasive breast carcinoma diagnosed by core needle biopsy 3. Maximum tumor size ≤1.5 cm in its greatest diameter 4. Ultrasound visible lesion(s) 5. Clinically node negative, hormone receptor positive (+). HER2 negative (-), with \<25% intraductal component in the aggregate. 6. Unilateral or bilateral disease meeting study criteria 7. Physical and emotional ability to undergo baseline and follow-up breast MRIs and serial breast cosmesis analysis 8. Patient agrees to receive a 5 year minimum course of endocrine therapy following cryoablation for control of systemic disease Exclusion Criteria: 1. Prior treatment (e.g., open surgical biopsy, lumpectomy) of index cancer 2. Ductal carcinoma in-situ with microinvasions (T1mic) 3. Multifocal or multicentric invasive breast carcinoma 4. Prior or planned neoadjuvant systemic therapy for breast cancer 5. Tumor with ≥25% IDC components