Development of an Integrated Positron Emission Tomography/Magnetic Resonance (PET/MR) System, Accessories and Components

Inclusion Criteria: * Subject must have a clinical indication for a PET/CT exam * Subject must be at least eighteen (18) years of age; and * Subject must be able to hear and understand instructions without assistive devices; and * Subjects must be ambulatory, and able to walk 350 feet without any assistive devices and climb 2 steps; and * Subject must be able to provide identification with photograph; and * Female subjects with negative urine pregnancy test performed within 24 hours prior to the clinical PET/CT imaging; and * Subject must provide written informed consent; and * Subject has the necessary mental capacity to understand instructions, and is able to comply with protocol requirements; and * Subject is able to remain still for duration of imaging procedure (approximately 60 minutes total for PET/MRI); and * Subject must be able to participate in a PET/MR imaging session within 1 hour of concluding their PET/CT exam Exclusion Criteria: * General Electric Healthcare (GEHC) employees; or * GEHC contractors; or * Healthcare providers (Any person in a position to purchase, lease, recommend, use, prescribe or arrange for the purchase or lease of any GEHC product or service that is reimbursable under any government program or private health insurance) or employees/contractors of medical device companies (as determined by self-report); or * Female subjects with known or suspected pregnancy; or * Subjects who have any axial diameter larger than 55 cm; or * Subjects with a weight greater than 227 kgs; or * Subjects who currently have, or have ever had a Cardiac Pacemaker or Defibrillator with implanted components; or * Subjects who are currently undergoing a gastrointestinal study involving swallowing of camera pill or similar device; or * Subjects who have any of the conditions below at the time of the scan session: * Prior negative experience or problem related to a previous MRI examination * Eye injury involving a metallic object * Potential for metal to be in body due to a previous injury involving metallic objects * Taking fertility medication or having fertility treatment * Cochlear, otologic or other ear implant * Insulin or other infusion pump * Implanted drug infusion device * Any type of prosthesis (eye, penile, etc) * Swan-Ganz or thermodilution catheter * Any metallic fragment or foreign body * Artificial or prosthetic limb * Bone/joint pin, screw, nail, wire, plate, etc * Neurostimulation system * Surgical staples, clips, or metallic sutures; * Implanted cardioverter defibrillator (ICD); * Magnetically activated implant or device; * Vascular access port and/or catheter; * Medication patch (Nicotine, Nitroglycerine); * Internal electrodes or wires; * External electronic medical device * Bone growth/bone fusion stimulator * Radiation seeds or implants * Heart valve prosthesis * Spinal cord stimulator * Eyelid spring or wire * Wire mesh implant * Tissue expander (e.g. breast) * Aneurysm clip(s) * Joint replacement (hip, knee, etc…) * Vascular or other stent(s), filter(s) or coil(s) * Intra-uterine device, diaphragm or pessary * Shunt (spinal or intraventricular) * Loose dental fillings * Dental fillings or crowns placed in the past 30 days * Tattoo or permanent makeup * Any implant * Breathing problem or motion disorder * Claustrophobia or panic attacks * Hearing Aid * Body piercing jewelry * Dentures or partial plates * External medical hardware (e.g. orthopedic braces) * Orthodontic appliances (e.g. braces, expanders) * Known or past allergic reactions to latex