Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients

N/AUnknownNCT01993342

Parc Taulí Hospital Universitari35 enrolled

Overview

The purpose of this study is to determine the concentration of different adipocytokine (adiponectin, leptin, resistin, visfatin, osteopontin) and an inflammation classic markers as Interleukine 1 beta, tumor necrosis alfa, interleukine 6 and high sensibility reactive c protein in the synovial fluid of knee osteoarthritis patients, and compare with the inflammation detected with ultrasonography evaluation of the joint. In last years, some studies appeared focusing on the role of adipocytokines in osteoarthritis and they correlated adipocytokines with cartilage degradation and x-ray degree; in our study we will focused in the importance of adipocytokines in the inflammatory changes more than in joint destruction.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Osteoarthritis

Interventions

arthrocentesisOTHER

The made a diagnostic arthrocentesis to all patient we included

Eligibility

Sex: ALLMin age: 50 YearsMax age: 81 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aged 50 to 81 * primary osteoarthritis of the knee * synovial effusion in examination * patient who have the results in our database Exclusion Criteria: * any other rheumatic conditions as rheumatoid arthritis or another inflammatory disease * secondary knee osteoarthritis * history of knee surgery * any conditions that at investigator criteria exclude the patient from study procedures

Outcomes

Primary Outcomes

Determination of adipocytokine levels (adiponectin, leptin, resistin, visfatin, osteopontin) in synovial fluid

We have all the synovial fluid freeze, so now we have to determine the levels of everyone.

Time frame: We determine adipocytoquines in one month, all patients in the same determination kit

Secondary Outcomes

Knee inflammation parameters detected by ultrasonography

We performed the ultrasonography evaluation at the same time than the visit were realized, and we have the results in a data base, so we will wait for the adipocytokine results and we will compare with ultrasound evaluation

Time frame: three months

To determine additional classic parameters of inflammation in synovial fluid as Interleukine 1 beta, Interleukine 6 and tumor necrosis factor alfa

We will use classic inflammation parameters to compare with adipocytokine levels

Time frame: We determine this inflammatory parameters in one month in all patient at the same time