Rapid Exchange Devices Observational Registry.

Inclusion Criteria: * Patients with symptomatic one or two legs ischemia, requiring treatment of SFA or popliteal artery * Rutherford classification 2-5 * Single lesion with recoiling/dissection/restenosis after balloon angioplasty or de novo lesions with stenosis or occlusion, * Target vessel reference diameter ≥4mm and ≤7mm (by visual estimate) * At least one patent (less than 50% stenosis) tibioperoneal run-off vessel confirmed by baseline angiography * Patient is suitable candidate for femoral-popliteal artery bypass surgery Exclusion Criteria: * Female of child-bearing potential. * Previous bypass surgery * In stent restenosis as a target lesion * Scheduled staged procedure of multiple lesions within the ipsilateral iliac or popliteal arteries within 30 days after index procedure. * Co-existing aneurysmal disease of the abdominal aorta, iliac or popliteal arteries * Acute thrombophlebitis or deep venous thrombosis * Hemodynamic instability * Untreated inflow disease of the ipsilateral pelvic arteries (more than 50 percent stenosis or occlusion), * Significant gastrointestinal bleeding or any coagulopathy that would contraindicate the use of anti-platelet therapy * Known intolerance to study medications, contrast agents or nitinol.