Postprandial Blood Cell Transcriptome of Normal Weight and Obese Subjects to 3 Caloric Doses of a High-fat Meal

N/ACompletedNCT01995110

Agroscope Liebefeld-Posieux Research Station ALP14 enrolled

Overview

The study will quantitatively evaluate the metabolic response of normal weight and obese subjects to three high-fat meals differing in caloric dose by analysing the postprandial blood transcriptome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Obesity Nutritional Intervention

Interventions

high-fat meal AOTHER

high-fat meal BOTHER

high-fat meal COTHER

Eligibility

Sex: MALEMin age: 25 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for normal weight subjects: * age 25-50 * 20\<BMI\>25 * waist circumference \<94cm Inclusion Criteria for obese subjects: * age 25-50 * 30\<BMI\>40 * waist circumference \>102cm Exclusion Criteria for both groups: * physiological or psychological diseases * allergies to food or intolerance to high-fat meal * vegetarians, vegans * chronic intake of drugs * smokers * diabetes mellitus type I and II * debiliating kidney disease * debiliating liver disease * clinically established coronary heart diseases * ingestion of vitamins or dietary supplements during the course of the study

Locations (2)

Agroscope

Bern, Canton of Bern, Switzerland

University Hospital Inselspital Berne

Bern, Canton of Bern, Switzerland

Outcomes

Primary Outcomes

blood cell transkriptome/ gene-expression

* differently expressed genes between normal weight and obese subjects at baseline * changes in gene-expression 2, 4 and 6h after consumption

Time frame: 0h, 2h, 4h, 6h

Data from ClinicalTrials.gov

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