Effect of Weight Loss on Cholesterol Metabolism in Hereditary Hypercholesterolemias and Overweight or Obesity.

Inclusion Criteria: * Age ≥18 years. * Diagnosis of Familial Combined Hyperlipidemia\* and Familial Hypercholesterolemia\*\*. * Body mass index \> 25 kg/m2. * Steady weight (±3 kg in the last 3 months). * Absence of lipid lowering drugs including sterols supplements in the previous 5 weeks. * Familial Combined Hyperlipidemia diagnosis was based on the presence of primary combined hyperlipidaemia in untreated patients whose serum cholesterol and triglyceride concentrations were above the sex- and age-specific 90th percentiles for the Spanish population, serum total apolipoprotein B concentration ≥ 120 mg/dL and there was at least one first-degree relative with hyperlipidemia (total cholesterol and/or triglycerides \>90th percentile) (Gómez-Gerique JA et al; 1999). * Familial Hypercholesterolemia was diagnosed in subjects with off-treatment LDL cholesterol concentrations above the age- and sex-specific 95th percentile of a Spanish reference population, triglyceride below 200 mg/dL and familial vertical transmission with at least one first-degree relative with LDL cholesterol above age- and sex-specific 95th percentiles (Gómez-Gerique JA et al; 1999). Exclusion Criteria: * Alcohol consumption \>30 gr/day. * Uncontrolled type-2 diabetes (HbA1c \>8%). * Any other disease that could interfere with the ability to comply with the study protocol were excluded * Personal history of cardiovascular disease, very high risk as defined by the presence of ≥ 2 major risk factors, or total cholesterol ≥ 350 mg/dL since lipid-lowering drug were considered highly recommended.