Safety and Immunogenicity Study of Prophylactic Streptococcus Pneumoniae Vaccine

Inclusion Criteria: 1. Males and non-pregnant females, ages 18 to 55 years inclusive. 2. Willing and able to provide written informed consent. 3. Willing to perform and comply with all study procedures including attending clinic visits as scheduled. 4. Willing to practice adequate contraception that may include, but is not limited to, abstinence, monogamous relationship with vasectomized partner, vasectomy, barrier methods such as condoms, diaphragms, intrauterine devices, and licensed hormonal methods for 28 days before and 90 days after receiving Study Drug. Exclusion Criteria: 1. Immunocompromised individuals, including those receiving immunosuppressive doses of corticosteroids (more than 20 mg of prednisone given daily or on alternative days for 2 weeks or more within 6 months prior to the first dose of Study Drug, any dose of corticosteroids within 30 days of the first dose of Study Drug, or high dose inhaled corticosteroids \[\> 960 µg/day of beclomethasone dipropionate or equivalent\]) or other immunosuppressive agents. 2. Presence or history of autoimmune disease, regardless of current treatment. 3. Insulin dependent diabetes. 4. Positive serologic test for HIV-1 or hepatitis C infection; positive hepatitis B surface antigen (HBsAg). 5. Screening serum chemistry or hematology abnormality ≥ Grade 1. 6. Screening urinalysis abnormality ≥ Grade 2. 7. Positive urine drug screen or alcohol Breathalyzer test at Screening or on Study Day 1. 8. Other active, uncontrolled co-morbidities that, in the opinion of the Investigator would make the subject unsuitable for the study or unable to comply with the study requirements. NOTE: Subjects who are taking a medication to control an underlying co-morbidity may be enrolled if there have been no changes to their medication within 60 days prior to the first dose of Study Drug. 9. Any acute illness including, fever (\>100.4 degrees F \[\> 38 degrees C\]) within 3 days prior to the first dose of Study Drug. 10. Pregnant or nursing women. 11. Receipt of any investigational drug within 30 days prior to the first dose of Study Drug. 12. Receipt of blood products within 90 days prior to the first dose of Study Drug. 13. Donation of blood or plasma within 56 days prior to Screening. 14. Receipt of a live vaccine within 28 days prior or a subunit vaccine within 14 days prior to the first dose of Study Drug or planned vaccination within 30 days following the last dose of Study Drug. 15. Prior vaccination with pneumococcal vaccine. 16. History of hypersensitivity to any component of the vaccine or history of an allergic reaction to an immunization. 17. History of invasive pneumococcal disease (i.e., sepsis, meningitis or pneumonia with bacteremia). 18. History of drug or alcohol abuse that, in the opinion of the Investigator, would interfere with the subject's ability to comply with the study requirements. 19. Any other condition that, in the opinion of the Investigator would make the subject unsuitable for the study or unable to comply with the study requirements.