EnligHTN German Observational Study of Renal Denervation for Uncontrolled Hypertension

Inclusion Criteria: * Subject is planned to undergo a renal denervation procedure for the treatment of hypertension * Subject is ≥18 years of age at time of consent * Subject must be able and willing to provide written informed consent * Subject must be able and willing to comply with the required follow-up schedule * Subject has office Systolic Blood Pressure (SBP) ≥ 140 mmHg * Subject has established hypertension (diagnosed ≥12 months prior to baseline) and is on a guideline based drug regimen at a stable (≥ 14 days) and a fully tolerated dose consisting of ≥3 anti-hypertensive medications (including 1 diuretic), or subject has documented drug intolerance to 2 or more of the 4 major classes of anti-hypertensives (ACE-I/ Angiotensin Receptor Blocker (ARB), Calcium Channel Blockers, Beta Blockers, or diuretic) and is unable to take 3 anti-hypertensive drugs Exclusion Criteria: * Subject has known significant renovascular abnormalities such as renal artery stenosis \> 30% * Subject has undergone prior renal angioplasty, renal denervation, indwelling renal stents, and/or abdominal aortic stent grafts * Subject has a history of hemodynamically significant valvular heart disease * Subject has blood clotting abnormalities * Subject life expectancy is \< 12 months, as determined by the Study Investigator * Subject is participating in another clinical study which has the potential