Immunologic Profile of Children With Severe Allergies to Peanuts and Nuts After Induction of Tolerance

Group 1: Inclusion Criteria: * Children (between 1 and 16 years old)known to have an allergy to peanuts and nuts detected by specific IgE, specific recombinant rArah (1 to 8) and R Cora and other allergens with a value superior or equal to 5KU/L. * Child, parents or legal representatives have given informed consent to participate in the study after being informed in details about the protocol. Exclusion Criteria: * Immunodeficiency, * Children or parents in disagreement with the study * Children without standard diagnostic test at recruitment (oral provocation test vs. placebo) * Children who reacted to placebo * Children with uncontrolled asthma or respiratory disease * Treatment with oral antihistaminic or corticoids one week before * Neither Healthcare coverage nor insurance Group 2: Inclusion criteria * Children (between 1 and 16 years old)known to have an allergy to peanuts and nuts detected by specific IgE, specific recombinant rArah (1 to 8) and R Cora and other allergens with a value superior or equal to 5KU/L * Doubling the values of the threshold after second oral challenge compared to the tests of reference * Child, parents or legal representatives have given informed consent to participate in the study after being informed in details about the protocol. Exclusion Criteria: * Immunodeficiency, * Children or parents in disagreement with the study * Children without standard diagnostic test at recruitment (oral provocation test vs placebo) * Children who reacted to placebo * Children with uncontrolled asthma or respiratory disease * Treatment with oral antihistaminic or corticoids one week before * Neither Healthcare coverage nor insurance Group 3: Inclusion criteria: * Children (between 1 and 16 years old) * No allergy to peanuts or nuts * No antecedents of atopia * Child, parents or legal representatives have given informed consent to participate in the study after being informed in details about the protocol Exclusion Criteria: * Immunodeficiency, * Children or parents in disagreement with the study * Children without standard diagnostic test at recruitment (oral provocation test vs. placebo) * Children who reacted to placebo * Children with uncontrolled asthma or respiratory disease * Treatment with oral antihistaminic or corticoids one week before * Neither Healthcare coverage nor insurance