The aim of this study is to assess whether dietary fiber-enriched cereals effect on postprandial glucose levels and plasma glucagon-like peptide 1 (GLP-1) and/or glucose-dependent insulinotropic polypeptide (GIP) concentration in patients with type 2 diabetes mellitus.
Fifteen subjects with type 2 diabetes mellitus will be provided with study meals based on either dietary fiber-enriched cereals or conventional cereals upon two separate admissions in a cross-over fashion. The study meals will be provided at 6 p.m. and 10 p.m. on the day of admission, and 8 a.m. on the next day. A hamburger with coke as mixed meal will be given for lunch at noon on the second day. Blood sampling will be done every 30 minutes from 8 a.m. to 4 p.m. on the second day. The plasma levels of glucose, GLP-1, GIP, insulin, glucagon, and free fatty acid will be measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
28
* provided with 300 mL (150 mL at 10 p.m.) of milk, total 3 times (day 1: 6 p.m. and 10 p.m., day 2: 8 a.m.) * amount: 79g for dinner and breakfast, 38.5g for night snack (10 p.m.) * one serving of steamed egg is added for dinner and breakfast
* provided with 300 mL (150 mL at 10 p.m.) of milk, total 3 times (day 1: 6 p.m. and 10 p.m., day 2: 8 a.m.) * amount: 80 g for dinner and breakfast, 40 g for night snack (10 p.m.) * one serving (40g) of steamed egg is added for dinner and breakfast
Seoul National University Hospital
Seoul, South Korea
Area Under the Curve (AUC) of Plasma Total GLP-1 Levels After Intake of the Study Meal
To see the changes in the secretion of GLP-1 with dietary fiber enriched cereal, we will calculate the AUC of the plasma total GLP-1 levels.
Time frame: every 30 minutes from 8 a.m. to noon on the second day
AUC of Plasma Total GIP Levels After Intake of the Study Meal
Time frame: every 30 minutes from 8 a.m. to noon on the second day
AUC of Plasma Glucose Levels After Intake of the Study Meal
Time frame: every 30 minutes from 8 a.m. to noon on the second day
AUC of Plasma Insulin Levels After Intake of the Study Meal
Time frame: every 30 minutes from 8 a.m. to noon on the second day
AUC of Plasma Glucagon Levels After Intake of the Study Meal
Time frame: every 30 minutes from 8 a.m. to noon on the second day
AUC of Serum Free Fatty Acid Levels After Intake of the Study Meal
Time frame: every 30 minutes from 8 a.m. to noon on the second day
AUC of Plasma Total GIP Levels After Lunch
Time frame: every 30 minutes from noon to 4 p.m. on the second day
AUC of Plasma Glucose Levels After Lunch
Time frame: every 30 minutes from noon to 4 p.m. on the second day
AUC of Plasma Insulin Levels After Lunch
Time frame: every 30 minutes from noon to 4 p.m. on the second day
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AUC of Plasma Glucagon Levels After Lunch
Time frame: every 30 minutes from noon to 4 p.m. on the second day
AUC of Serum Free Fatty Acid Levels After Lunch
Time frame: every 30 minutes from noon to 4 p.m. on the second day
AUC of Plasma Total GLP-1 Levels After Lunch
Time frame: every 30 minutes from noon to 4 p.m. on the second day