To explore electrophysiologic parameters and biomarkers predicting treatment response of patients with major depressive disorder To explore electrophysiologic parameters and biomarkers predicting suicide risk of patients with major depressive disorder
Case-control study Repeated measures design
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
600
SSRI antidepressant
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
RECRUITINGChange in baseline frequency of maximum of cross-spectrum during 6 weeks (Hz)
the link between the normalized high frequency component of heart rate variability (HRV-HFnu) representing cardiac vagal modulation and frontal alpha power related to resting state
Time frame: 0, 3, 7, 14, and 42 days
Change in cardiorespiratory coupling during 6 weeks
change in value of cross-sample entropy measured by combining sample entropies of heart rate and respiration
Time frame: 0, 3, 7, 14, and 42 days
Change in HF during 6 weeks
change in high frequency component of heart rate variability
Time frame: 0, 3, 7, 14, and 42 days
Change in persistent homology during 6 weeks
change in disconnection pattern of EEG channel activities measured by Euclidean distance during 6 weeks
Time frame: 0, 3, 7, 14, and 42 days
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