Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease

N/ACompletedNCT01998204

Changhai Hospital62 enrolled

Overview

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and pulse generator placement under general anesthesia. Abnormal pharmacodynamics might be present among these patients, which had never been investigated.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Parkinson's Disease

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement under general anesthesia * non-Parkinsonian patients without Parkinson's disease undergoing intracranial surgery under general anesthesia Exclusion Criteria: * ASA score higher than Class III * predicted difficult airway * hearing impairment * inability to corporate with instruction * alcohol or drug abuser * patients refusing to provide informed consent

Locations (1)

Department of Anesthesiology, Changhai Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

Consciousness status

Consciousness status is evaluated by the observer's assessment of alertness and sedation score (OAA/S).

Time frame: Participants will be monitored during the period of propofol infusion, an expected average of less than 10 min

Data from ClinicalTrials.gov

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