Continuous Blood Purification for Regulation of Early Inflammatory Response In Severe Acute Pancreatitis

Inclusion Criteria: Inclusion Criteria: 1. Diagnosis of pancreatitis: * Typical pain * Increase in serum lipase or amylase * Onset of abdominal pain within \<=72h before admission 2. The diagnosis criteria of Severe Acute Pancreatitis is according to Atlanta criteria revisited in 2012 3. no chronic diseases such as Chronic Obstructive Pulmonary Disease, Diabetes Mellitus and so on 4. Age from 18 to 65 years old Besides criteria above, the patient should also satisfied one of these CBP criteria: 1. Have Acute Kidney Injury satisfied RIFLE classification (risk above): increased Serum Creatinine \> 1.5 times baseline，26.5umol/L increase, or urine output \< 0.5ml/kg.h for 6 hours 2. Systemic Inflammatory Response Syndrome: temperature \>38℃ or\<36℃；heart rate respiratory rate White blood cell count \>12\*10\^9/L，or\< 4\*10\^9/L 3. Refractory acid-base and electrocyte balance disorder, metabolic acidosis conservative treatment is not effective. Exclusion Criteria: 1. Pregnancy 2. Chronic pancreatitis 3. Immunosuppression condition such as HIV, Corticosteroid for 3 weeks in 60 days; White Blood Cell \< 0.5\*10\^9/L for 10 days