Prothrombotic Factors and Anaesthesia in Prostate Cancer

Inclusion Criteria: * newly diagnosed cancer of the prostate * histological Gleason score evaluation. Exclusion Criteria: * ASA \>2 * metabolic equivalent task \< 4 * BMI\>30 * no pre-operative pharmacological thromboprophylaxis and/or anti-coagulant therapy * history of abnormal bleeding, or abnormal coagulant factors * sepsis within the last 2 weeks * previous new adjuvant treatments (chemo, hormone, and radiotherapy) * non-steroid , anti-inflammatory and statins drugs for at least 2 wks before surgery * venous or arterial thromboembolism within the last 3 months, peripheral venous disease * neurological disease with extremity paresis * chronic liver disease * pre-operative haemoglobin concentration \< 9 mg dl-1 * prolonged duration of surgery (\>3 hrs) * peri-operative blood transfusion * not adequate material for laboratory testing