The study is a single center randomised, double-blind, placebo-controlled crossover study to assess the effects of beetroot juice in patients with pulmonary arterial hypertension.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
15
Uppsala University Hospital
Uppsala, Sweden
Change in VO2 submax and or VO2 max
Time frame: 7 days
Change in 6MWT
Time frame: 7 days
Change in WHO functional class
Time frame: 7 days
Change in echocardiographic parameters
Change in; pulmonary artery systolic pressure (PASP), ventricular diastolic function, systolic right and left ventricular function, right and left atrial/ventricular dimensions will be calculated
Time frame: 7 days
Change in exhaled NO
Time frame: 7 days
Change in systemic bloodpressure
Time frame: 7 days
Change in metabolic pathways involved in nitric oxide production and regulation
Change in the following biochemical variables will be calculated; ADMA, SDMA, Arginine, Citrulline, Ornithine, uric acid, nitrate, nitrite
Time frame: 7 days
Change in NT-pro-BNP
Time frame: 7 days
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