The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
80
General anesthesia combined with thoracic epidural 1% lidocaine
General anesthesia combined with thoracic epidural 0.25% bupivacaine
General anesthesia combined with thoracic epidural 0.3% ropivacaine
Propofol Effect-site Concentration
The effect-site concentration of propofol when loss of consciousness during propofol target-controlled infusing(TCI) induction of anesthesia.
Time frame: Before starting anesthesia to finishing endotracheal intubation
Mean Arterial Pressure
The mean arterial pressure of each patient was recorded at five different time points
Time frame: Before starting anesthesia to finishing endotracheal intubation
Heart Rate
The heart rate of each patient was recorded at five different time points
Time frame: Before starting anesthesia to finishing endotracheal intubation
Bispectral Index Score
The bispectral index(BIS) score of each patient was recorded at two different time points. BIS values varies from 0 to 100(0, no cerebral activity; 40 to 60, general anesthesia; 60 to 85, sedated; 85 to 100, awake).
Time frame: Before starting anesthesia to finishing endotracheal intubation
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General anesthesia combined with thoracic epidural 0.9% normal saline